Panama’s Tocumen Airport is Central America’s busiest and largest, the only one with two active runways. Getting to Panama City isn’t a crazy-long flight from most of the United States (from Miami, it’s less than three hours). The country is served by Air Canada, Air France, American, Copa, Delta, KLM, Lufthansa, United and others. Local air service extends to most part of the country. No visa is required for U.S. citizens.